Bone Abstracts

Polyphosphates (polyPs) are inorganic phosphate chains found in many cell types with higher concentrations in bone cells. As a source of inorganic phosphate (Pi) and an effective calcium reservoir due to chelation, PolyPs enable total Ca2+ and PO42− concentrations above those required for apatite saturation. Alkaline phosphatase (ALP) cleaves Pi from polyP, thus polyPs may be involved in apatite mineralization.Aim: ...

Bone is a tough composite material, comprised of a compliant collageneous matrix, brittle apatite mineral crystals and a suite of non-collageneous proteins (NCPs). Bone material properties depend on these components, and their interactions at the mineral-collagen interface. ‘Bone mineral density’ (BMD), a parameter used to predict fracture risk, is routinely quantified by DEXA. Previous studies used ex vivo emu tibiae as a model to test the effect of organic...

Titanium implants have been extensively used in dentistry as a replacement of absent dental elements. The biocompatibility of a material depends on cellular response in contact with a surface. The microarray technology is a tool to obtain an overview of the cell state in terms of large-scale transcriptional expression in different situations. Thus, the objective of this investigation was to evaluate the transcriptional profile of osteoblastic cells from human alveolar bone cul...